Minimal dose of a stimulus for maximal pepsin secretion.

neous (Kay, 1953) or intravenous (Lawrie, Smith & Forrest, 1964) histamine acid phosphate (HAP) and subcutaneous (Makhlouf, McManus & Card, 1966) or intravenous (Konturek & Lankosz, 1967) pentagastrin (ICI 50123). However, similar dose-response curves to determine the minimal dose of a stimulus for maximal pepsin secretion are not reported. In various studies, the doses of different stimuli which had caused a maximal acid secretion were administered to stimulate maximal pepsin secretion, on the assumption that parietal and chief cells have some definite relationship both in health and disease in all individuals. The object of this study was to perform doseresponse curves with different stimuli with a view to determine the minimal doses for maximal pepsin secretion.